Find out about the symptoms, causes, and treatment of chondrosarcoma, a type of bone cancer most common in your pelvis, thighbone, or upper arm. Cartilage tumor adjacent to fishflesh appearance of sarcoma. Pathology of primary malignant bone and cartilage tumours. The prognosis of chs is closely related to histologic grading. Differential diagnosis of cartilaginous lesions of bone archives of.
Radiation oncologysarcomachondrosarcoma wikibooks, open. Theodore locke phillips md, facr, fastro, in leibel and phillips textbook of. Photograph of a coronally sectioned gross specimen of a conventional intramedullary chondrosarcoma of the femur demonstrates a multilobulated lesion replacing a long extent of the marrow space c. Clinical features of bone tumours are often nonspecific or not recognised, and as a consequence they often are not detected in the early phases. Based on the morphologic feature alone, a correct diangosis of chs may be difficult, therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of chs. Picmonic is research proven to increase your memory retention and test scores. Webpathology is a free educational resource with 10308 high quality pathology images of benign and malignant neoplasms and related entities. Andrew horvai, in bone and soft tissue pathology, 2010. Chondrosarcoma, rare malignant tumour of bone formed from cartilage. The neoplasm was grade ii and exhibited overexpression of the p53 tumor suppressor. Correlation between gross, radiographic, and microscopic features of the.
Chondrosarcomas are divided into three grades based upon their histopathology. Examples of singleuser license include conferences, seminars, presentations, and onetime teaching courses. Herein, we present a case of a 65yearold woman with a rare chondrosarcoma of the spine, who presented with clinical symptoms from the lung metastasis. It is a rare cancer that accounts for about 20% of bone tumors and is diagnosed in approximately 600 patients each year in the united states. Chondrosarcoma chs is a malignant cartilageforming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Chondrosarcoma dedifferentiated pathology outlines. Netherlands, 1998 pmid 9667567 intracranial chondrosarcoma. Two foci of deep endosteal scalloping greater than twothirds of the normal cortical thickness with expansile remodeling of bone arrows are seen. Mesenchymal chondrosarcoma is a rare, highgrade malignancy of bone or soft tissue with a. They are frequently seen in the 4th and 5th decades with a slight male predominance 1.
In fact, in one study, 50% of chondrosarcomas were greater than 10 cm in size, occupying from 30% to more than 50% of the bone length, fig 1, 8. Malignant bone tumours are rare neoplasms with an incidence of around one to two new cases per 100,000 individuals per year. Most commonly intraosseous but can occur in extraskeletal sites especially the central nervous system from the meninges. Distinguishing a low grade chondrosarcoma as in this case from and enchondroma is generally not possible macroscopically and relies on. Rare variant of chondrosarcoma 210% of primary chondrosarcomas.
Chondrosarcoma high quality pathology images of orthopedic. The degree of calcification can indicate the relative age of the lesion and its maturation. Often, chondrosarcoma is overlooked as a possible diagnosis. Laryngeal chondrosarcoma is a rare tumor requiring clinical, histologic, and radiographic correlation for definitive diagnosis. Extraskeletal chondrosarcoma is a rare type of chondrosarcomadoes, which forms in the soft tissues, rather than bone cartilage. The senior editors and authors of this book are well recognized and highly regarded bone and soft tissue pathologists and radiologists. Associated with preexisting enchondroma, but not with chondroblastoma, osteochondroma, fibrous dysplasia or pagets disease. Often large painful tumors of long bones or ribs that grow rapidly during adolescence and reach 8 cm or larger. Mar 29, 2014 details of the image chondrosarcoma grade i gross pathology modality. Chondrosarcoma musculoskeletal medicine for medical. Rushing, reappraisal of mesenchymal chondrosarcoma. Chondrosarcoma can occur at any age but is more common in people older than 40 years. Learn chondrosarcoma bone tumors pathology picmonic for physician assistant faster and easier with picmonics unforgettable images and stories. The commonest sub type of chondrosarcoma is conventional chondrosarcoma which may be low, intermediate or high grade.
Canine extraskeletal osteosarcoma and chondrosarcoma. Chondrosarcoma is the third most common primary malignancy of bone, affecting primarily the pelvic and shoulder girdles and being extremely rare in the spine. Chondrosarcoma is a malignant tumor composed of cartilageproducing cells. May 24, 2016 low grade chondrosarcoma 10 year survival rate 90% high grade chondrosarcoma 10 year survival rate 2040% recurrence generally have higher grade than primary malignancy bcoz slow growing tumour and recurrence or mets cant be detected years after primary procedure long term follow up with regular imaging of operative site and chest. The typical presentation is in the 4 th and 5 th decades and there is a slight male predominance of 1. Chondrosarcomas can develop in any place where there is cartilage. Description chondrosarcoma is a malignant tumor whose cells produce cartilage.
At gross pathologic examination, juxtacortical chondrosarcoma arises on the surface of. The best procedure for you will be determined by the cancers stage and location. Unlike other primary bone cancers that mainly affect children and adolescents, chondrosarcoma can present at any age. The disease usually starts in the bones of the arms. B, gross photograph demonstrating a secondary chondrosarcoma arising in.
This position is analogous to that of the pathologists, who do not use. Focused chondrosarcoma with stained slides of pathology. Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce cartilage. Ct scan and gross pathology of a chondrosarcoma 20121218. Gross pathology handbook fills a much needed niche for a reference of terms and examples in gross dissection of autopsy and surgical pathology specimens. This book is distributed under the terms of the creative commons. Chondrosarcoma is a member of a category of tumors of bone and soft tissue known as sarcomas. This book makes the authors knowledge and their approach to bone pathology accessible in an organized and systematic fashion. The patient was referred to the authors institution where confirmation of a lowgrade grade 1 chondrosarcoma was made figure 2. Click download or read online button to get pathology and genetics of tumours of soft tissue and bone book now. Fluoroquinolones effect on grwoth of human chondrocytes and chondrosarcomas. Patnaikdepartment of pathology, the animal medical center, new york, ny abstract. Bone pathology is one of the most subspecialized and challenging areas of pathology.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Files are available under licenses specified on their description page. Unlike other primary bone cancers that mainly affect children. Gross photograph of tumor mass showing pearly white cartilaginous tissue with irregular surface. Extension through articular cartilage and through ligaments may occur. Mesenchymal chondrosarcoma is aggressive variant of chondrosarcoma, which tend to occur in younger people. Dnyandeo yashwantrao patil medical college, nerul, navi mumbai, maharashtra, india. Primary or conventional chondrosarcoma arises in preexisting normal bone. It is the second most common primary malignancy of bone, and one of the most difficult bone tumors to diagnose and treat. It includes the latest diagnostic information in this challenging subspecialty, while its unique image collection serves as an exceptional educational aid. At gross pathologic evaluation, conventional intramedullary chondrosarcomas are large lesions, the majority being greater than 4 cm in size, 1, 7.
Oclcs webjunction has pulled together information and resources to assist library staff as they consider how to handle. Patients usually present with pain, pathological fracture, a palpable lump or local mass effect. Numerous and frequentlyupdated resource results are available from this search. Chondrosarcoma symptoms, prognosis, treatment, survival. Chondrosarcomas are malignant cartilaginous tumors that account for 25% of all primary malignant bone tumors. Usually a good prognosis 75% five year survival in one large data set. In most other domestic species, chondrosarcoma is a relatively rare tumor, and too few cases are reported to provide reliable information on its clinicopathologic features. This site is like a library, use search box in the. In general, these tumors are multilobulated due to hyaline cartilage nodules with central high water content and peripheral endochondral ossification. Malignant cartilage forming tumor that does not produce osteoid.
Chondrosarcoma is primarily a tumor of adulthood with a wide age distribution 20s to. Testicular ultrasound is imaging modality of choice for a scrotal mass semin ultrasound ct mr 20. Primary chondrosarcomas arise from a small collection of cartilage cells. Grade and stage are independent predictors of survival. On imaging, these tumors have ringandarc chondroid matrix mineralization with.
Although it typically presents with lowgrade histology, even highgrade histology has a fairly indolent progression in this location, with a relatively lowlikelihood for metastatic potential or recurrence. All structured data from the file and property namespaces is available under the creative commons cc0 license. What is chondrosarcoma what are the symptoms of chondrosarcoma. Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signaling. Stunning image collection includes gross pathology, histopathology, immunohistochemistry, fish, and correlative radiologic imaging to serve as an exceptional educational aid. The surgeon removes the tumor along with some surrounding healthy tissue. Pathology and genetics of tumours of soft tissue and bone. Reliable information about the coronavirus covid19 is available from the world health organization current situation, international travel. This is unfortunately normal unless scans are done in the beginning of the process of diagnosis. Gordos guide to gu pathology ch 7, pg 190192, 204 ct or mri can detect retroperitoneal masses, consistent with metastatic teratoma semin ultrasound ct mr 20. Chondrosarcoma is a cancer composed of cells derived from transformed cells that produce. Extraskeletal myxoid chondrosarcoma emc is a rare softtissue sarcoma, which primarily occurs deep in the extremities, especially in skeletal muscle, or tendon.
Gross finding of clear cell chondrosarcoma in the proximal femur. Emc of the pleura has been described, however, no case of primary emc arising from lung has been previously reported. Definition and pathogenesis primarily arising secondarily from a surface exostosis or periosteal chondroma, either low grade i or intermediate grade ii in grade importance must be differentiated from an osteochondroma or periosteal chondroma a dx of m. Chondrosarcoma grades iiii, including primary and secondary variants and periosteal chondrosarcoma.
Chondrosarcoma is a type of sarcoma that affects the bones and joints. Reviewed all cases of intracranial chondrosarcoma in the netherlands and available data in the literature. About 30% of skeletal system cancers are chondrosarcomas. Bone was designed for practicing pathologists who need access to uptodate, comprehensive, and concise bone pathology knowledge in one convenient place. Unmineralized areas of lucency especially adjacent to densely mineralized areas are worrisome for a relatively immature region of the lesion or a spindle cell area secondary chondrosarcoma or dedifferentiated chondrosarcoma. Examples of multiuser license include books, book chapters, educational material, and other publications with multiple copies. We describe herein, a 51yearold asian female initially manifested with. Aug 30, 2006 malignant bone tumours are rare neoplasms with an incidence of around one to two new cases per 100,000 individuals per year. Childhood tumors usually involve extremities and are often chondroblastic osteosarcomas. However, formatting rules can vary widely between applications and fields of interest or study. This exceptionally illustrated reference is invaluable to pathology laboratories, students, pathologist assistants, and residents, as they build detailed and precise specimen descriptions, the foundation of an accurate diagnosis. Multhaupt hab, alvarez jc, rafferty pa, warhol mj, lackman rd. Specifically designed as a pointofcare resource, the updated third. Low grade chondrosarcoma 10 year survival rate 90% high grade chondrosarcoma 10 year survival rate 2040% recurrence generally have higher grade than primary malignancy bcoz slow growing tumour and recurrence or mets cant be detected years after primary procedure long term follow up with regular imaging of operative site and chest.
Authored and updated by experts in the field, diagnostic pathology. Symptoms of chondrosarcoma may vary depending on the location and size of the cancer. Subtypes vary substantially chondrosarcoma nos and myxoid chondrosarcoma have a five year survival of 70%, but mesenchymal chondrosarcoma only 50%, and dedifferentiated chondrosarcoma an abysmal 0%. Conventional intramedullary chss are large lesions, usually greater than. On gross examination, conventional chondrosarcomas appear smooth, hard, and lobulated. Pathology the histology of chondrosarcomas can differ according to their subtype see below. After age 20, the risk of getting a chondrosarcoma goes up until about age 75.
Chondrosarcoma arising in an intramedullary location has also been termed central chondrosarcoma to contrast with peripheral chondrosarcoma arising in association with osteochondroma. Bone will be an essential guide to understanding bone tumor pathology and diagnosis. Webpathology is a free educational resource with 10197 high quality pathology images of benign and malignant neoplasms and related entities. Chondrosarcoma grade i gross pathology radiology case.
Covering all aspects of soft tissue pathology, this highly regarded volume in the diagnostic pathology series is an excellent pointofcare resource for pathologists at all levels of experience and trainingboth as a quick reference and as an efficient re. Clinicians who treat chondrosarcoma patients must determine the grade of the tumor, and must ascertain the likelihood of metastasis. Chondrosarcoma is a cartilage forming neoplasm, which is the second most common primary malignancy of bone. Webpathology is a free educational resource with 10304 high quality pathology images of benign and malignant neoplasms and related entities. Details of the image chondrosarcoma grade i gross pathology modality. Surgical options for chondrosarcoma include biopsy described above, limbsparing surgery, and amputation. World health organization classification of tumours of soft tissue and bone, 4th ed, fletcher cdm, bridge ja, hogendoorn pcw, mertens f eds, iarc, lyon 20. A 19 year old female patient presented with chondrosarcoma in left mandibular region near angle of mouth.